Detail info about the product:
Packing: 30 tablets 500 mg
Micronized purified flavonoidic fraction (diosmin 450 mg, hesperidin 50 mg).
Each tablet contains micronized flavonoid fraction 500 mg (diosmin 450 mg and hesperidin 50 mg).
Detralex 500 also contains the following excipients: Carboxymethylcellulose sodium, microcrystalline cellulose, gelatin, magnesium stearate, talc, white beeswax, glycerol, hydroxypropylmethylcellulose (2910), polyethylene glycol 6000, sodium lauryl sulfate, yellow iron oxide, red iron oxide and titanium dioxide.
The innovation with Detralex 500 consists of the micronization of its active constituent from particles of 30-60 microns to particles of <2 microns. This new and optimized form allows Detralex 500 to increase venous tone from the first 2-tab dose and by the 1st hour and provides Detralex 500 with added clinical efficacy.
Detralex 500 is a phlebotonic drug and a vascular protecting agent.
The efficacy of Detralex 500 is accounted for by its specific action on the principal elements of venous disease.
Detralex 500 is phlebotonic: It reinforces venous tone by prolonging the activity of parietal noradrenaline. Thus, Detralex 500 decreases venous capacitance, venous distensibility and venous emptying time.
Detralex 500 protects the microcirculation by fighting the microcirculation-damaging process; it combats venous inflammation by decreasing leukocyte activation, and as a consequence, by inhibiting the release of inflammatory mediators, principally free radicals and prostaglandins. Thus, Detralex 500 normalizes capillary permeability and strengthens capillary resistance.
Detralex 500 acts on the lymphatic system: It improves lymphatic drainage by increasing lymph flow and lymph oncotic pressure. This action on the lymphatic system associated with a phlebotonic and vasculoprotective effect, explains the activity of Detralex 500 on CVI-associated edema.
Double-blind, placebo-controlled studies have demonstrated Detralex 500ís efficacy on chronic venous insufficiency. Detralex 500 significantly improves disabling symptoms of venous insufficiency which affect everyday active life: Heavy legs, pain, heat sensation, edema, functional impairment, nocturnal cramps and restless legs.
In addition to conventional compression therapy, Detralex 500 has also demonstrated to cure 3 times as many venous leg ulcers as placebo, and to accelerate their complete healing.
Detralex 500 is highly effective in the treatment of chronic hemorrhoidal disease. It significantly improves subjective symptoms and objective signs, eg anal discomfort, pain, redness, anal discharge, proctitis, tenesmus, pruritus, erythema and bleeding. Detralex 500 also significantly reduces the frequency, severity and duration of acute hemorrhoidal attacks.
Indication Organic & functional chronic venous insufficiency of the lower limbs; heavy legs, pain, nocturnal cramps. Hemorrhoidal disease, acute hemorrhoidal attacks.
Chronic venous insufficiency 2 tab daily. Acute hemorrhoidal attacks 6 tab/day for the 1st 4 days, then 4 tab/day for 3 days, 2 tab thereafter. Chronic hemorrhoids 2 tab daily.